Random Analytica

The World Health Organisation (WHO) has updated it latest advice on the Ebola Outbreak. Ebola Response Roadmap Situation Report 7 November 2014. Summary:

A total of 13 268 confirmed, probable and suspected cases of Ebola virus disease (EVD) have been reported in six currently affected countries (Guinea, Liberia, Mali, Sierra Leone, Spain, the United States of America) and two previously affected countries (Nigeria, Senegal) up to the end of 4 November 2014. There have been 4960 reported deaths.

Following the WHO Ebola Response Roadmap structure, country reports fall into two categories: 1) those with widespread and intense transmission (Guinea, Liberia, and Sierra Leone); and 2) those with or that have had an initial case or cases, or with localized transmission (Mali, Nigeria, Senegal, Spain, and the United States of America).

Here are three charts/infographics of the West African Outbreak with data confirmed by WHO to 5 November 2014.

The West African Ebola Outbreak (2013-2014) infographic details the cases, fatalities, provisional Case Fatality Rate (CFR) and health spend per capita in 2012 $USD.

The data point of interest for me in the past fortnight has been the revision in numbers that WHO has provided. In the most recent update case numbers in Sierra Leone have been significantly revised down, while in Liberia where cases are on the apparent wane the numbers were revised upwards. Data for Mali has been included in this update.

The West African Ebola Outbreak (by Nation) chart looks at the split between those recovered or still in treatment (highlighted by flag) and those deceased (in red).

A data point of interest here is the case difference between Sierra Leone and Guinea yet a similar amount of deaths. Provisional CFR is Sierra Leone is 23.2% compared to Guinea which is a much higher 59.9%. Surely that can’t be correct?

The West African EVD Outbreak – All Cases/Fatalities by month details the epidemiological curve of the outbreak from March 2014 when the first cases and deaths became apparent. Each column is visualised by the flag of the eight impacted countries. Note: Due to revisions in late October as provided by WHO I have finalised the October numbers as at 2 November.

The data point of interest in the last chart is the epidemic curve differences between cases (still rising) and deaths (decreasing). I would have expected that both should increase or decrease in tandem. I suspect missing data would account for the anomaly.

Summary

I’ll update and post my charts again when the data becomes available for the entirety of November. In the meantime if you want to keep across the West African outbreak detail via some alternate sources then I would recommend Crawford Kilian and for more regular epidemiological posts Maia Majumder, MPH and Ian Mackay, PhD.

Data Sources

[1] World Bank. Health expenditure per capita (current US$). Accessed 8 November 2014.
[2] World Health Organisation. WHO: Ebola Response Roadmap Situation Report 7 November 2014. Accessed 8 November 2014.

The World Health Organisation (WHO) has updated it latest advice on the Ebola Outbreak. Ebola Response Roadmap Situation Report 22 October 2014. Summary:

Summary

A total of 9936 confirmed, probably, and suspected cases of Ebola virus disease (EVD) have been reported in five affected countries (Guinea, Liberia, Sierra Leone, Spain, and the United States of America) and two previously affected countries (Nigeria and Senegal) up to the end of 19 October. A total of 4877 deaths have been reported.

The outbreaks of EVD in Senegal and Nigeria were declared over on 17 October and 19 October 2014, respectively.

EVD transmission remains persistent and widespread in Guinea, Liberia, and Sierra Leone. All but one administrative district in Liberia and all administrative districts in Sierra Leone have now reported at least one confirmed or probably case of EVD since the outbreak began. Cases of EVD transmission remain lowest in Guinea, but case numbers are still very high in absolute terms. Transmission remains intense in the capital cities of the three most affected countries. Case numbers continue to be under-reported, especially from the Liberian capital Monrovia.

Of the countries with localized transmission, both Spain and the United States continue to monitor potential contacts. On 21 October the single patient with EVD in Spain tested negative for the disease for a second time. Spain will be declared free of EVD 42 days after the date of the second negative test unless a new case arises during that period.

On 22 October 2014, WHO convened the third Emergency Committee on Ebola under the International Health Regulations (2005).

Here are three charts or infographics of the West African Outbreak with data confirmed by WHO to 18/19 October 2014.

The West African Ebola Outbreak (2013-2014) infographic details the cases, fatalities, the provisional Case Fatality Rate (CFR) and health spend per capita in 2012 $USD.

Midway through October the biggest data find for me has been the difference between the index cases in Senegal and the United States. Lots of similarities but IMO four very important differences:

1. Both cases entered the country without disclosing the possibility that they may have been exposed to Ebola;
2. Both cases presented to hospital shortly after arrival in the destination country;
3. Difference One: In the case of Thomas Eric Duncan who travelled to the USA he presented at hospital but was released back into the community. He presented again three days later (interestingly a key and important fact left out of the official CDC Overview) with more extreme symptoms. In the Senegal case the patient sought treatment in Dakar giving no indication he may have Ebola but was not released and a day later Senegalese authorities linked him to other cases. He was subsequently quarantined;
4. Difference Two: In the USA contract tracing was slow to be implemented while PPE protocols were inadequate which resulted in the spread of the disease amongst Health Care Workers (HCW). In Senegal no HCW were infected.
5. Difference Three: The USA index case died of the disease; potentially due to those critical days where he was without care while in Senegal the patient recovered and has returned to Guinea.
6. Difference Four (and this is the key one which you can see in the infographic): The average health spend per capita in the USA is $8,895 (in 2012 $USD money) while Senegal makes do with just $51 per person. That’s 174 times less than the USA.

The West African Ebola Outbreak (by Nation) chart looks at the split between those recovered or still in treatment and those deceased. As per the latest update from WHO there is an element of underreporting going on in the worst impacted countries (Liberia, Sierra Leone and Guinea).

The West African EVD Outbreak – All Cases/Fatalities by month details the epidemiological curve of the outbreak from March 2014 when the first cases and deaths became apparent. Each column is visualised by the flags of the seven impacted countries.

The mid-month data-find from this chart is that the epidemic curve in relation to deaths continues to increase month on month yet the case load seems to be pulling back. All the anecdotal evidence coming out of West Africa points to an increasing, rather than a decreasing case load as individuals, families and population centres avoid health care facilities. In past months, the case load mid-month would be approximately equal to the previous month. Best case scenario would be that West Africa is getting on top of the disease but the facts-on-the-ground don’t support this. I’d expect to see some revisions to the data in coming weeks and months.

Summary

I’ll update and post my charts again when the data becomes available for the entirety of October. In the meantime if you want to keep across the West African outbreak detail via some alternate sources then I would recommend Crawford Kilian and for more regular epidemiological posts Maia Majumder, MPH and Ian Mackay, PhD.

Data Sources

[1] World Bank. Health expenditure per capita (current US$). Accessed 23 October 2014.
[2] World Health Organisation. WHO: Ebola Response Roadmap Situation Report 22 October 2014. Accessed 23 October 2014.